Control of cellular physiology by E2F transcription factors

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Research Signpost , Kerala, India
Cell physiology, Transcription fa
Statementeditor Kenichi Yoshida.
ContributionsYoshida, Kenichi, Dr.
The Physical Object
Pagination435 p. :
ID Numbers
Open LibraryOL23198922M
ISBN 139788130802305
LC Control Number2009341735

An important control point in this balance occurs in the G, phase of the cell cycle. Transcriptional Control of Control of cellular physiology by E2F transcription factors book Growth The E2F Gene Family. Editors: Farnham, Peggy (Ed.) Free Preview. Buy this book eB08 € price for Spain (gross) Buy eBook ISBN.

Transcriptional control by E2F. Adams PD(1), Kaelin WG Jr. Author information: (1)Dana Farber Cancer Institute, Boston, MA, USA. Considerable evidence suggests that the E2F/DRTF1 family of transcription factors (hereafter referred to as 'E2F') plays a critical role in cell growth by: The activity of E2F transcription factors plays a crucial role in mammalian cell-cycle progression and is controlled by physical association with the pocket proteins (pRb and its related p and.

E2F proteins, the E2F1 transcription factor is of special interest because of its contrasting behavior under cellular stress conditions, which sets it apart from all other members of the family. E2F1 may act as an oncogene or as a tumor suppressor, probably depending on.

The family of E2F/dimerization partner (DP) transcription factors are key components of the cyclin/retinoblastoma/E2F pathway that participate in controlling cell cycle transitions in multicellular. The p53 pathway (ARF–p53–cell cycle arrest or apoptosis related effectors) The tumor suppressor p53 is a transcription factor that is activated by a variety of stress signals, including DNA damage, hypoxia and various oncogenic changes including aberrant activation of E2F [].In response to such stress signals, p53 induces either cell cycle arrest or by: 1.

The retinoblastoma tumour suppressor (Rb) pathway is believed to have a critical role in the control of cellular proliferation by regulating E2F activities. E2F1, E2F2 and E2F3 belong to a subclass of E2F factors thought to act as transcriptional activators important for progression through the G1/S by: There are six members of the E2F family of transcription factors, E2F-1 through E2F-6 [6].

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In a heterodimeric complex with one member of the DP family of proteins, the E2F proteins regulate the activity of promoters containing E2F binding sites. E2F target genes encode S-phase-regulatory proteins, such as CDC6, Cited by: E2F proteins are a family of transcription factors that play a key role in regulation of the cell cycle, DNA replication and development in both animals and plants (Ramirez-Parra et al., ; van den Heuvel and Dyson, ; Lammens et al., ).

Eight E2F proteins have been described in. E2F is a group of genes that encodes a family of transcription factors in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells.

E2Fs as TFs bind to the TTTCCCGC consensus binding site in the target promoter sequence. E2F transcription factor family is closely related to the process of cell proliferation, differentiation and apoptosis. Most of its members can regulate the transcription of downstream target genes by forming heterodimers with DP molecule, and interact with pRb and cyclin dependent kinases to Author: Peishan Liu, Xiaoyue Zhang, Zhengshuo Li, Lingyu Wei, Qiu Peng, Can Liu, Yangge Wu, Qun Yan, Jian Ma.

Details Control of cellular physiology by E2F transcription factors EPUB

Transition from G 1 (G 0) to S phase is a critical step in the control of the cell cycle, as well as a mitotic step. The control of this process closely involves E2F transcription factors in by: In book: Control of Cellular Physiology by E2F Transcription Factors, Publisher: Transworld Research Network, Editors: Kenichi Yoshida, pp Cite this publication Kiyoshi Ohtani.

E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in progression through G1 and into the S-phase of the cell cycle.

The activity of E2F factors is regulated through association with the retinoblastoma tumor suppressor protein (Rb) and the other pocket proteins, p and pCited by: Transcription Factors in the Control of Tumor Development and Progression by TGF-β Signaling Function of the E2F Transcription Factor Family During Normal and Pathological Growth.

transformation eukaryote gene therapy genes genomic biology pathophysiology physiology transciption factor biology transcription transcription factors zinc. Strikingly, only a few transcriptional regulators are known, although a significant amount of the genome is transcribed in a cell cycle phase-dependent manner.

E2F–DP transcription factors and three repeat MYB proteins are responsible for the expression of genes at the G1-to Cited by:   The E2F family of transcription factors is believed to have an essential role in the control of cellular proliferation by regulating the transcription of genes involved in cell cycle progression.

Previous work has demonstrated that the targeted inactivation of E2f1, E2f2, and E2f3 results in elevated p21(CIP1) protein levels, loss of E2F target Cited by: The E2F gene family of transcription factors is a regulator of the G1 to S phase transition of the mammalian cell cycle.

This volume details which cellular genes are thought to be regulated by E2F and describes models for E2F action based on protein-protein complexes that influence cell growth.

The relevance of cell cycle regulation also has an impact on the physiology of the gastrointestinal tract as the epithelium is composed of rapidly proliferating cells. The E2F transcription factor is a cellular target for the RB protein.

Cell, 65 (6) (), pp.

Description Control of cellular physiology by E2F transcription factors FB2

de Bruin l of cell cycle transcription during G1 and S Cited by: 5. The retinoblastoma tumour suppressor (Rb) pathway is believed to have a critical role in the control of cellular proliferation by regulating E2F activities. E2F1, E2F2 and E2F3 belong to a subclass of E2F factors thought to act as transcriptional activators important for Cited by: Temporal control of cell cycle gene expression mediated by E2F transcription factors.

Zhu W(1), Giangrande PH, Nevins JR. Author information: (1)Duke Institute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolinaby: Function.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.

The E2F proteins contain several evolutionally conserved domains Aliases: E2F2, E2F-2, E2F transcription factor 2. Function. The protein encoded by this gene is a member of the E2F family of transcription E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.

The E2F proteins contain several evolutionarily conserved domains found in most members of the s: E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F.

Request PDF | The E2F transcription factors: Key regulators of cell proliferation | Ever since its discovery, the RB-1 gene and the corresponding protein, pRB, have been a focal point of cancer. Phosphorylation of Rb and its relatives by Cdk2 and -4 results in the release of E2F complexes, enabling them to activate transcription and trigger the expression of genes required for DNA synthesis and further cell cycle regulating molecules such as cyclin E, cyclin A, the mitotic kinase Cdc2 (p34/Cdk1), and E2F-1 Cited by:   Historically, the ability of RB to regulate the cell cycle placed it in a central role in proliferative control, and research focused on RB regulation of the E2F family of transcription by:   The balance between cell proliferation and differentiation is crucial in multicellular organisms, where it is regulated by complex gene expression networks.

This is particularly relevant in plants because organogenesis is a continuous postembryonic process. Here, we investigate the function of Arabidopsis thaliana E2Ff, an atypical member of the E2F family of transcription factors, which Cited by:   Transgenic Arabidopsis thaliana plants overproducing the E2Fa-DPa transcription factor have two distinct cell-specific phenotypes: some cells divide ectopically and others are stimulated to endocycle.

The decision of cells to undergo extra mitotic divisions has been postulated to depend on the presence of a mitosis-inducing factor (MIF). Plants possess a unique class of cyclin-dependent.

E2F is a transcription factor for a number of cell cycle genes that are critical for G 1 -to-S transition in mammalian cells (49, 68).

This family of transcription factors binds to and is inactivated by a second family of proteins known as pocket proteins, the prototypical member being the Rb gene product. Endoreplication, also called endoreduplication, is a cell cycle variant of multicellular eukaryotes in which mitosis is skipped and cells repeatedly replicate their DNA, resulting in cellular polyploidy.

In recent years, research results have shed light on the molecular mechanism of endoreplication control, but the function of this cell-cycle variant has remained by:. Precise control of the mitotic cell cycle is a critical feature of eukaryotic life.

In humans, mutations in cell cycle regulatory genes lead to the uncontrolled cell proliferation and tumor formation associated with the most dreaded of all diseases, cancer. E2F transcription factors are keyCited by: 1.

One of the most common themes in the process of tumorigenesis is deregulation of the cell cycle, especially in factors that control the G1/S transition, which heavily relies on the activity of E2F transcription factors. The E2F family consists of eight transcription factors that fall into two groups depending on whether they activate Cited by:   The E2F transcription factors are key components of the cyclin/retinoblastoma/E2F pathway that control cell cycle transitions in multicellular organisms (Gutierrez et al., ).

In humans, ASF1B is regulated by E2F transcription factors during cell cycle progression (Hayashi et al., ).